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Substrates or Inhibitors of CYP2C19 Blood levels and or toxicity of propranolol for propranolol overnattning torsk may be increased by co-administration with substrates or inhibitors of CYP2C19, such as fluconazole, cimetidine, fluoxetine, fluvoxamine, tenioposide, and tolbutamide. In women, none of the metabolic clearances for propranolol showed any significant association with either estradiol or testosterone. Propranolol may change thyroid-function tests, increasing T4 and reverse T3, and decreasing T3. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.