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To times higher than predicted from foto femara prasky the concentrations measured after single dose, indicating slight non-linearity in the pharmacokinetics of letrozole upon daily administration of. Patients had received other hormonal therapies and also may have received cytotoxic therapy. Glucocorticoid or mineralocorticoid supplementation is, therefore, not necessary. In each study over 60 of the patients had received therapeutic antiestrogens, and about one-fifth of these patients had had an objective response.