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Patients should also be told that drowsiness or somnolence can occur with Doxazosin mesylate or doxazosin lakare any selective alpha1 adrenoceptor antagonist, requiring caution in people who must drive or operate heavy machinery. Sustained improvements with Doxazosin mesylate were seen in patients treated for up to 14 weeks in double-blind studies and up to years in open-label studies. Adverse reactions with an incidence of less than but of clinical interest are Doxazosin mesylate vs. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs. Does Doxazosin Oral have any side effects?Doxazosin Oral Precautions Before taking doxazosin, tell your doctor or pharmacist if you are allergic to or to other alpha blockers such as prazosin and or if you have any other allergies. CARDURA treatment was superior to placebo in improving patient symptoms and urinary flow rate.