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In vitro and in vivo data indicate that nifedipine can inhibit the metabolism of drugs that are substrates of CYP3A, thereby increasing the exposure to other drugs. There are no adequate and well-controlled studies in pregnant women. There is literature report of reversible reduction in the ability of human sperm obtained from limited number of infertile men taking recommended comprar nifedipine sin rx doses of nifedipine to bind to and fertilize an ovumin vitro. The degree of serum protein binding of nifedipine is high 92-98.
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